Intrahepatic cholestasis of pregnancy: molecular pathogenesis, diagnosis and management.

نویسندگان

  • F Lammert
  • H U Marschall
  • A Glantz
  • S Matern
چکیده

Frank Lammert, Hanns-Ulrich Marschall1, Anna Glantz2 and Siegfried Matern Department of Internal Medicine III, Aachen University of Technology – RWTH, Aachen, Germany, 1Karolinska Institutet, Department of Medicine, Division of Gastroenterology and Hepatology, Huddinge University Hospital, Stockholm, and 2Department of Obstetrics and Gynecology, Sahlgren’s University Hospital, East, Göteborg, Sweden

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Management of Hepatic Cholestasis

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Intrahepatic cholestasis of pregnancy.

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Dermatoses unique to pregnancy are important to recognize for the clinician as they carry considerable morbidity for pregnant mothers and in some instances constitute a risk to the fetus. These diseases include pemphigoid gestationis, polymorphic eruption of pregnancy, intrahepatic cholestasis of pregnancy, and atopic eruption of pregnancy. This review discusses the pathogenesis, clinical impor...

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Management of Intrahepatıc Cholestasıs of Pregnancy: Revıew of Lıterature

Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy specific liver disorder characterized by maternal pruritus in the latter half of the pregnancy, raised serum bile acids and increased rates of adverse fetal outcomes. Maternal effects of ICP are mild; however, there is a clear association between ICP and higher frequency of fetal distress, preterm delivery, and sudden intrauterin fetal ...

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Alanine aminotransferase as a predictor of adverse perinatal outcomes in women with intrahepatic cholestasis of pregnancy

OBJECTIVE To evaluate the associations between adverse perinatal outcomes and serum transaminase levels at the time of diagnosis in patients with intrahepatic cholestasis of pregnancy. METHODS We performed a retrospective analysis of patients hospitalized for evaluation of intrahepatic cholestasis of pregnancy from January 2013 to June 2014 in a tertiary center. Seventy-one patients were divi...

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عنوان ژورنال:
  • Journal of hepatology

دوره 33 6  شماره 

صفحات  -

تاریخ انتشار 2000